منابع مشابه
Dispersal of Golgi matrix proteins during mitotic Golgi disassembly.
During mitosis, the mammalian Golgi disassembles into numerous vesicles and larger membrane structures referred to as clusters or remnants. Following mitosis, the vesicles and clusters reassemble to form an intact Golgi in each daughter cell. One model of Golgi biogenesis states that Golgi matrix proteins remain assembled in mitotic clusters and then serve as a template for Golgi reassembly. To...
متن کاملW(H)ither the Golgi during Mitosis?
During mitosis, the entire content of the cell must be divided equally between two daughter cells before karyoand cytokinesis are completed. How is this complex process accomplished? In the case of the Golgi, it was found many years ago in tissue culture cells that the characteristic stack-like organization of the Golgi fragmented at the onset of mitosis (Robbins and Gonatas, 1964; Lucocq and W...
متن کاملERK1c regulates Golgi fragmentation during mitosis
Extracellular signal-regulated kinase 1c (ERK1c) is an alternatively spliced form of ERK1 that is regulated differently than other ERK isoforms. We studied the Golgi functions of ERK1c and found that it plays a role in MEK-induced mitotic Golgi fragmentation. Thus, in late G2 and mitosis of synchronized cells, the expression and activity of ERK1c was increased and it colocalized mainly with Gol...
متن کاملMyosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development.
Polarized membrane addition is crucial for axon development and elongation during neuronal morphogenesis. This process is believed to be regulated by directed membrane trafficking of Rab10-containing post-Golgi carriers. However, the mechanisms underlying the biogenesis of these carriers remain unclear. Here, we report that Rab10 interaction with myosin Vb (MYO5B) determines the formation of Ra...
متن کاملMutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis.
The conserved oligomeric Golgi (COG) complex plays essential roles in Golgi function, vesicle trafficking and glycosylation. Deletions in the human COG7 gene are associated with a rare multisystemic congenital disorder of glycosylation that causes mortality within the first year of life. In this paper, we characterise the Drosophila orthologue of COG7 (Cog7). Loss-of-function Cog7 mutants are v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2011
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a005363